Blood Flow Measurements in Microvessels

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  • SEKI Junji
    国立循環器病センター研究所生体工学部

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  • 微小血管における血流計測法
  • ビショウ ケッカン ニ オケル ケツリュウ ケイソクホウ

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Abstract

Blood flow rate in microvessels whose diameter is less than 100μm is an important factor in determining mass transport of oxygen, nutrients etc. as well as in determining production of biologically active substances such as nitric oxide. Several flow measuring techniques used for experimental microciculatory studies are reviewed. A dual-slit photometric method is a most widespread technique and has moderate temporal and spatial resolutions but it lacks a spatial resolution in the line-of-sight direction. A dual-window method using conventional video signals has a merit of simultaneous velocity measurements in multiple microvessels but its temporal resolution is inadequately low. A laser-Doppler method has sufficiently high temporal resolution to analyze pulsatile flow in small animals and fits for surface microcirculation of solid organs as well as transparent tissues. Image processing method of optical flow and a high-frequency pulsed-wave Doppler ultrasound method are promising in the near future.

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