Basic studies for discogenic low back pain

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  • 腰痛の基礎研究　　椎間板性腰痛に関する基礎研究
  • 椎間板性腰痛に関する基礎研究
  • ツイカンバンセイ ヨウツウ ニ カンスル キソ ケンキュウ

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This paper reviews the basic researches for discogenic low back pain. The review revealed the following findings. The lumbar intervertebral disc may be innervated non-segmentally through the paravertebral sympathetic nerve and segmentally through the sinuvertebral nerves. The lumbar intervertebral disc may be innervated by dichotomizing sensory fibers. Exposure of the nucleus pulposus to the outside of the anulus fibrosus may induce nerve injury and ingrowth into the disc. NGF-dependent neurons are predominant in the rat intervertebral disc, indicating hyperalgegic responses can be induced by inflammation. NGF in the NP may promote the axonal growth. Lumbar fusion may inhibit nerve ingrowth into the degenerated disc, and reduce percentage of CGRP-immunoreactive neurons. Discogenic low back pain has a character of visceral pain.

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