書誌事項
- タイトル別名
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- Hemostatic Management with Prothrombin Complex Concentrate in a Patient with Factor VII Deficiency Undergoing Resection of a Large Ovarian Cyst
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説明
A 24-year-old Japanese woman with congenital factor VII deficiency (factor VII less than 0.01U/ml) developed a large cyst in the right ovary. She had a history of recurrent joint bleeding and menorrhagia that had been treated with prothrombin complex concentrate (PCC, Proplex® ST). She underwent right adnectomy successfully with repeated replacement therapy using Proplex® ST (1, 755 U of FVII: C per vial). Pharmacokinetics study of Proplex® ST revealed that the biological half-life and in vivo recovery of FVII: C were 5.6h and 152%, respectively. Two vials of Proplex® ST were given prior to surgery and every 8 hours until 48 hours after surgery, yielding a peak plasma FVII: C level of approximately 1.62U/ml and a trough level of 0.16U/ml. Subsequently, one vial was given every 8 hrs until 16 hours after surgery, resulting in a peak level of 1.07U/ml and a trough level of 0.08U/ml. The administration interval of PCC was prolonged thereafter and the replacement therapy was terminated on the 6th postoperative day. No abnormal bleeding or thrombotic events occurred during the perioperative course.
収録刊行物
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- 日本血栓止血学会誌
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日本血栓止血学会誌 11 (2), 193-200, 2000
一般社団法人 日本血栓止血学会
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詳細情報 詳細情報について
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- CRID
- 1390001204444593920
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- NII論文ID
- 10008601265
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- NII書誌ID
- AN10353762
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- ISSN
- 18808808
- 09157441
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
- OpenAIRE
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- 抄録ライセンスフラグ
- 使用不可
