The Role of Biomarkers in Detecting Early Changes Relating to Exposure to Occupational Carcinogens.

DOI Web Site Web Site Web Site 参考文献173件
  • SHAHAM Judith
    Occupational Cancer Unit, Occupational Health and Rehabilitation Institute at Loewenstein Hospital and Preventive Medicine, Sackler School of Medicine, Tel-Aviv University
  • RIBAK Joseph
    Occupational Cancer Unit, Occupational Health and Rehabilitation Institute at Loewenstein Hospital and Preventive Medicine, Sackler School of Medicine, Tel-Aviv University

書誌事項

タイトル別名
  • Role of Biomarkers in Detecting Early C

この論文をさがす

説明

The Role of Biomarkers in Detecting Early Changes Relating to Exposure to Occupational Carcinogens: Judith SHAHAM et al. Occupational Cancer Unit, Occupational Health and Rehabilitation Institute at Loewenstein Hospital-Increasing evidence points to the role of chemical exposure in the etiology of cancer. Approximately 4% (1-10%) of all deaths due to cancer are caused by occupational carcinogens. In recent years carcinogenic mechanisms have been equated with a continuum multistage process driven by carcinogen induced genetic and epigenetic damage. This process reflects the natural history of chemically induced neoplasia and is translated into the latency period. The development and implementation of laboratory techniques to detect biomarkers that reflect these changes provide opportunities for early diagnosis of both occult and preneoplastic tumors. In order to facilitate the use of biomarkers in the assessment of health risk, they have been divided into categories that represent the continuum between different stages involved in the carcinogenic process from exposure to disease. Thus, the focus of biomarkers has been on the internal dose, biological effective dose and biological response and their use has become an integral part of molecular epidemiology. Biomarkers are useful in strengthening the causality between exposure and malignant transformation or to serve as an indicator warning of a potential carcinogen when epidemiological data concerning the exposure-disease relationship is inconclusive or unavailable. A battery of markers that reflect different stages of the carcinogenesis process can be used to provide information on the etiology of occupational cancer, to monitor exposed populations, and to identify high risk populations in order to encourage appropriate surveillance with regard to cancer prevention, although there are ethical issues regarding risk assessment. (J Occup Health 1996; 38: 170-178)

収録刊行物

参考文献 (173)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ