Carcinogenicity and Chronic Toxicity after Inhalation Exposure of Rats and Mice to <i>N,N</i>‐Dimethylformamide
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- Senoh Hideki
- Japan Bioassay Research Center
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- Aiso Shigetoshi
- Japan Bioassay Research Center
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- Arito Heihachiro
- Japan Bioassay Research Center
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- Nishizawa Tomoshi
- Japan Bioassay Research Center
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- Nagano Kasuke
- Japan Bioassay Research Center
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- Yamamoto Seigo
- Japan Bioassay Research Center
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- Matsushima Taijiro
- Japan Bioassay Research Center
書誌事項
- タイトル別名
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- Carcinogenicity and Chronic Toxicity after Inhalation Exposure of Rats and Mice to N, N-Dimethylformamide
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Carcinogenicity and chronic toxicity of N,N-Dimethylformamide (DMF) were examined by inhalation exposure of groups of 50 rats and 50 mice of both sexes to DMF vapor at a concentration of 0, 200, 400 or 800 ppm (v/v) for 6 h/d, 5 d/wk, for 104 wk. In rats, incidences of hepatocellular adenomas and carcinomas significantly increased in the 400 and 800 ppm-exposed groups and in the 800 ppm-exposed group, respectively. The hepatocellular adenoma did not increase significantly in the 400 ppm-exposed female rats, but its incidence exceeded a range of historical control data in the Japan Bioassay Research Center (JBRC). In mice, incidences of hepatocellular adenomas and carcinomas significantly increased in all the DMF-exposed groups. Incidence of hepatoblastomas significantly increased in the 200 and 400 ppm-exposed male mice, and 4 cases of hepatoblastomas in the 400 ppm-exposed female mice and the 800 ppm-exposed male mice exceeded the range of historical control data of the JBRC. Incidences of altered cell foci increased in the liver of exposed rats and mice in an exposure concentration-related manner, and those foci were causally related to the hepatocellular tumors. Liver weights increased in both rats and mice exposed to DMF at 200 ppm and above. Increased levels of γ-GTP, ALT, AST and total bilirubin in exposed rats of both sexes and AST and ALT in exposed mice of both sexes were noted. It was concluded that 2-yr inhalation exposure to DMF increased incidences of hepatocellular adenomas and carcinomas in rats and incidences of hepatocellular adenomas, carcinomas and hepatoblastomas in mice, and that hepatocarcinogenicity of DMF was more potent in mice than in rats.<br>
収録刊行物
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- journal of Occupational Health
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journal of Occupational Health 46 (6), 429-439, 2004
公益社団法人 日本産業衛生学会
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詳細情報 詳細情報について
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- CRID
- 1390001204454082944
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- NII論文ID
- 130004447237
- 110003723229
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- NII書誌ID
- AA11090645
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- COI
- 1:STN:280:DC%2BD2cnjslyrug%3D%3D
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- ISSN
- 13489585
- 13419145
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- NDL書誌ID
- 7177537
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- PubMed
- 15613765
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可