Metabolism of Terbufos in Rat Liver
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- LI Jin-Tong
- Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences
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- SHENG Shi-Jie
- National Center of Biomedical Analysis
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- DU Xian-Lin
- Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences
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Abstract
Metabolism of Terbufos in Rat Liver: Jin-Tong Li, et al. Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing, China, 100850—Biotransformation of terbufos in rat liver revealed four metabolites in the effluent prepared with a C18 cartridge after the rat liver was perfused for one hour in situ. Analysing the spectrogram of GC-IR and GC-MS, metabolite IV appeared to be an oxidative desulfuration product of terbufos with the formula C9H21O3PS2, the recovery of which in the effluent was 2.13%; metabolite I appeared to be an hydrolysate of metabolite IV with the formula C5H13O3PS, the recovery of which was 0.13%; metabolite II appeared to be an hydrolysate of terbufos with the formula C5H13O2PS2, the recovery of which was 2.65%; metabolite III appeared to be a methylate of metabolite 11, with the formula C6H15O2PS2, the recovery of which was 1.42%. Relatively the recovery of terbufos was 40.8%. These results were in accord with the regular metabolic pattern in vivo of phosphorothioates with a thioether group.
Journal
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- Journal of Occupational Health
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Journal of Occupational Health 41 (2), 62-68, 1999
Japan Society for Occupational Health
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Details 詳細情報について
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- CRID
- 1390001204455669760
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- NII Article ID
- 130003527412
- 110003723030
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- NII Book ID
- AA11090645
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- ISSN
- 13489585
- 13419145
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- NDL BIB ID
- 4747015
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed