Time Course of Blood Parameters in Printing Workers with Cholangiocarcinoma
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- Kumagai Shinji
- Department of Occupational and Environmental Management, University of Occupational and Environmental Health
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- Kurumatani Norio
- Department of Community Health and Epidemiology, Nara Medical University School of Medicine
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- Arimoto Akira
- Department of Hepato-Biliary-Pancreatic Surgery, Osaka Red Cross Hospital
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- Ichihara Gaku
- Department of Occupational and Environmental Health, Faculty of Pharmaceutical Sciences, Tokyo University of Science
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Objectives: We previously reported a cluster of cholangiocarcinoma patients among proof-printing workers who were exposed to 1,2-DCP for a long term. The present study was conducted to evaluate blood parameters in these proof-printing workers during and after exposure. Methods: Health examination records during employment and after retirement were obtained for ten cholangiocarcinoma patients to analyze their blood parameters. The patients and/or their relatives were also interviewed about lifestyle and occupational history. Results: All study patients were exposed to 1,2-DCP for 6–17 years. Red blood cells, hemoglobin, hematocrit, total cholesterol, triglycerides, and fasting plasma glucose were within the standard ranges for almost all patients, but the γ-glutamyl transpeptidase (γ-GTP) levels exceeded the standard range during 1,2-DCP exposure for six patients. Two of the six patients were diagnosed with cholangiocarcinoma during 1,2-DCP exposure, and the other four patients were diagnosed 1–9 years after termination of exposure. The remaining four patients had γ-GTP levels within the standard range during 1,2-DCP exposure, but had increased γ-GTP levels thereafter, and were diagnosed with cholangiocarcinoma 4–10 years after termination of exposure. Aspartate aminotransferase and alanine aminotransferase levels started to increase following the increase in γ-GTP levels. Conclusions: Workers exposed to 1,2-DCP should be provided with periodic health examinations during and after exposure. In the examination, even small increases in γ-GTP levels should be considered a signal of early development of cholangiocarcinoma.(J Occup Health 2014; 56: 279-284)
収録刊行物
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- journal of Occupational Health
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journal of Occupational Health 56 (4), 279-284, 2014
公益社団法人 日本産業衛生学会
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詳細情報 詳細情報について
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- CRID
- 1390001204455782528
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- NII論文ID
- 130004694135
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- NII書誌ID
- AA11090645
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- COI
- 1:STN:280:DC%2BC2cjislOntw%3D%3D
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- ISSN
- 13489585
- 13419145
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- NDL書誌ID
- 025619841
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- PubMed
- 24826961
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- PubMed
- CiNii Articles
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