Relations between Exposure to <i>o</i>‐Dichlorobenzene and Concentrations of Urinary Metabolites

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  • MATSUNAGA Ichiro
    Department of Occupational Health, Osaka Prefectural Institute of Public Health
  • KUMAGAI Shinji
    Department of Occupational Health, Osaka Prefectural Institute of Public Health

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  • Relations between Exposure to o-Dichlorobenzene and Concentrations of Urinary Metabolites.
  • Relations between Exposure to o Dichlor

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Relations between Exposure to o-Dichlorobenzene and Concentrations of Urinary Metabolites: Shinji KuMAGAI, et al. Department of Occupational Health, Osaka Prefectural Institute of Public Health—The present study aimed to examine the relation between exposure to airborne o-dichlorobenzene (o-DCB) and concentrations of four urinary metabolites, i.e., 3, 4-dichlorocatechol (3, 4-DCC), 4, 5-dichlorocatechol (4, 5-DCC), 2, 3-dichlorophenol (2, 3-DCP) and 3, 4-dichlorophenol (3, 4-DCP). Subjects were ten male workers exposed to o-DCB in synthesizing intermediate products for dyes. Individual exposure to o/-DCB was monitored with a passive dosimeter. Urine samples were collected during the workshift and at the end of the workshift. The concentrations of urinary 3, 4-DCC, 4, 5-DCC, 2, 3-DCP and 3, 4-DCP were determined with a high performance liquid chromatograph. The mean recovery rates for urinary metabolites obtained by our analytical method were 93.2 to 102% with coefficients of variance of 2.7 to 7.5%. The concentrations of 3, 4-DCC, 4, 5-DCC, 2, 3-DCP and 3, 4-DCP in urine collected at the end of the workshift and those during the last four hours of the workshift were shown to be well correlated to the 8-hr time weighted average (8-hr TWA) value for the exposure concentration of o-DCB. The mean ratios (as moles) of 3, 4-DCC to 4, 5-DCC, that of 2, 3-DCP and that of 3, 4-DCP at the end of the workshift were 0.78, 0.42 and 0.37, respectively. The time series of the concentrations of the four metabolites showed that these concentrations varied with time in a similar pattern. (J Occup Health 1997; 39: 124-129)

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