Human Herpesvirus 6 Reactivation in Trichloroethylene‐exposed Workers Suffering from Generalized Skin Disorders Accompanied by Hepatic Dysfunction
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- Huang Hanlin
- Hospital for Occupational Diseases Control of Guangdong Provinc
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- Kamijima Michihiro
- Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine
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- Wang Hailan
- Hospital for Occupational Diseases Control of Guangdong Provinc Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine
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- Li Senhua
- Hospital for Occupational Diseases Control of Guangdong Provinc
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- Yoshikawa Tetsushi
- Department of Pediatrics, Fujita Health University School of Medicine
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- Lai Guanchao
- Hospital for Occupational Diseases Control of Guangdong Provinc
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- Huang Zhenlie
- Hospital for Occupational Diseases Control of Guangdong Provinc
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- Liu Huifang
- Hospital for Occupational Diseases Control of Guangdong Provinc
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- Chen Jiabin
- Hospital for Occupational Diseases Control of Guangdong Provinc
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- Takeuchi Yasuhiro
- Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine
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- Nakajima Tamie
- Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine
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- Li Laiyu
- Hospital for Occupational Diseases Control of Guangdong Provinc
書誌事項
- タイトル別名
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- Human Herpesvirus 6 Reactivation in Trichloroethylene-exposed Workers Suffering from Generalized Skin Disorders Accompanied by Hepatic Dysfunction
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抄録
Idiosyncratic generalized skin disorders resembling serious drug hypersensitivities have reportedly occurred after occupational exposure to trichloroethylene. However, factors associated with the disorders remain unknown except for trichloroethylene exposure. This study aimed at clarifying whether infectious diseases contributed to the development of rash or hepatitis in patients with trichloroethylene-related generalized skin disorders. Fifty-nine patients consecutively hospitalized between March 2002 and December 2003 and 59 healthy exposed workers selected on an age-matched basis in the patients' factories were enrolled in the study. Information on possible risk factors for rash and hepatitis was collected with structured checklists. Antibody titers were measured for hepatitis A, B and C viruses, Mycoplasma pneumoniae, herpes simplex viruses 1 and 2, Epstein-Barr virus, cytomegalovirus, human herpesvirus 6, measles and rubella virus. Thirty-six cases (59%) showed exfoliative dermatitis, 17 (28%) erythema multiforme, 4 (7%) Stevens-Johnson syndrome, and 4 (7%) toxic epidermal necrolysis. Before the onset of rash, 16 (27%) cases had received medication prescribed for the preceding fever, a main first symptom of the disorders. Marked increases in anti-human herpesvirus 6 IgG titer (≥256), which indicated viral reactivation, were noted in 14 (25%) patients, while no abnormal increase was detected in the controls (p<0.001). Anti-measles IgM titer was positive in 2 (7%) cases but not in the controls (p=0.49). The involvement of other known risk factors of rash or hepatitis was ruled out. These results suggest that part of trichloroethylene-related generalized cutaneous disorders occurring in China and drug-induced hypersensitivity syndrome overlap in terms of human herpesvirus 6 reactivation.<br>
収録刊行物
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- journal of Occupational Health
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journal of Occupational Health 48 (6), 417-423, 2006
公益社団法人 日本産業衛生学会
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詳細情報 詳細情報について
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- CRID
- 1390001204456856704
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- NII論文ID
- 130004447368
- 110004863655
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- NII書誌ID
- AA11090645
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- COI
- 1:CAS:528:DC%2BD2sXisFagtrw%3D
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- ISSN
- 13489585
- 13419145
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- NDL書誌ID
- 8564031
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- PubMed
- 17179634
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可