Genetic Epidemiological Studies of Longevity-Associated Mitochondrial DNA 5178 C/A Polymorphism
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- KOKAZE Akatsuki
- Department of public Health, Kyorin University School of Medicine
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説明
Mitochondrial DNA 5178 cytosine/adenine (Mt5178 C/A) polymorphism is associated with longevity in the Japanese population, and the Mt5178A genotype may confer antiatherogenic advantages. Individuals with the Mt5178A genotype may be more resistant to adult-onset diseases, such as myocardial infarction, cerebrovascular diseases and type 2 diabetes, than those with the Mt5178C genotype. Moreover, Mt5178 C/A polymorphism has been reported to be associated with blood pressure, serum lipid levels, hematological parameters, intraocular pressure, serum protein fraction levels and serum electrolyte levels in healthy Japanese individuals. Differences in the influence of habitual drinking or habitual smoking on health status between the Mt5178C genotype and the Mt5178A genotype have been reported. The individual modification of drinking habits or smoking habits based on the genotyping of Mt5178 C/A may promote improved health and lead to the establishment of personalized prevention strategies for adult-onset diseases.<br>
収録刊行物
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- Environmental Health and Preventive Medicine
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Environmental Health and Preventive Medicine 10 (6), 319-323, 2005
一般社団法人日本衛生学会
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詳細情報 詳細情報について
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- CRID
- 1390001204457011072
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- NII論文ID
- 10016883987
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- NII書誌ID
- AA1108348X
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- ISSN
- 13474715
- 1342078X
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- PubMed
- 21432114
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
- KAKEN
- OpenAIRE
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- 抄録ライセンスフラグ
- 使用不可