Characteristics and Effects of Muscle Fibers surrounding Lingual Carcinoma

DOI Web Site 被引用文献2件 参考文献25件
  • Sakiyama Koji
    Division of Anatomy, Department of Human Development and Fostering, Meikai University School of Dentistry
  • Takizawa Shota
    Division of Anatomy, Department of Human Development and Fostering, Meikai University School of Dentistry Division of Maxillofacial-2, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry
  • Bando Yasuhiko
    Division of Anatomy, Department of Human Development and Fostering, Meikai University School of Dentistry
  • Inoue Katsuyuki
    Division of Maxillofacial-2, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry
  • Sasaki Au
    Division of Orthodontics, Department of Human Development and Fostering, Meikai University School of Dentistry
  • Kurokawa Katsuhide
    Department of Sports Dentistry, Tokyo Dental College
  • Shimoo Yoshiaki
    Department of Anatomy, Tokyo Dental College
  • Suzuki Masafumi
    Department of Anatomy, Tokyo Dental College
  • Abe Shinichi
    Department of Anatomy, Tokyo Dental College
  • Amano Osamu
    Division of Anatomy, Department of Human Development and Fostering, Meikai University School of Dentistry

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It has been suggested that dysphagia caused by excision of carcinoma of the tongue may be affected by the hypofunction of the surrounding muscle tissues, as well as by tissue defects. However, there have been no reports concerning how muscle fiber characteristics change in the regions surrounding the lesion after excision of the carcinoma. In this study, we investigated myosin heavy chain (MyHC) isoforms at genetic levels in order to demonstrate the muscle fiber characteristics of the muscle tissues surrounding lingual carcinoma (the experimental group). High mobility group box 1 (HMGB1) was used as a marker to examine whether tongue cancer actually developed. MyHC-2a expression was high in the experimental group. Thus, the marked changes of muscle fiber characteristics, as seen in this study, were considered to be a biological reaction to changing muscle characteristics for regenerating or maintaining normal muscle tissues against the muscle atrophy caused by carcinoma.

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