Exploring the Effect of Surgical Operations on the Oral Microflora of Human Oral Carcinoma

DOI Web Site 参考文献18件
  • Hua Lin
    Department of Prosthetic Dentistry, West China College of Stomotology, Sichuan University
  • Rui Huang
    Department of Prosthetic Dentistry, West China College of Stomotology, Sichuan University
  • Xinying Zheng
    Department of Prosthetic Dentistry, West China College of Stomotology, Sichuan University
  • Qingyan Li
    Department of Prosthetic Dentistry, West China College of Stomotology, Sichuan University
  • Ning Gao
    Department of Prosthetic Dentistry, West China College of Stomotology, Sichuan University

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Squamous cell carcinoma is a frequently occurring malignant tumor in the human oral cavity. Its treatment usually includes surgical removal of the tissue with pathological changes, as well as radiotherapy and chemotherapy. Surgical removal of the cancerous tissue (combined radical operation) will unavoidably lead to changes in the tissue structure in the local area, and consequently result in changes in the varieties and amounts of the colonized flora. There are currently no reports regarding this possibility. The purpose of this study was to investigate the distribution of bacterial flora in the lesion area of oral squamous cell carcinoma before and after operations. The results obtained from this investigation may be used as a reference point in the treatment of oral squamous carcinoma and the prevention of postoperative infection.The objective of this study was to investigate the distribution of bacterial flora in the lesion area of oral squamous cell carcinoma, before and after operations, and to determine the effects of surgical manipulations on oral bacteria. Forty-two subjects with oral squamous cell carcinoma were selected, each was diagnosed definitively by biopsy and histology, and a combined radical operation was performed. The total number of viable colonies of bacteria as well as the isolation frequency and constituent ratio of each kind of bacteria in the lesion area were measured before and after the operations.In the preoperative lesion of oral squamous cell carcinoma, Streptococci constituted 69.15% of the isolates; Prevotella, 2.47%: Neisseria, 6.70%; Gram-positive anaerobic bacilli, 4.68%; Gram-negative anaerobic bacilli, >4.17%; and other bacteria made up less than 4.07% of the flora. In the postoperative lesion, Streptococci made up 76.99% of the total value; Prevotella, 10.93%; Gram-positive anaerobic bacilli, 6.30%, and other bacteria <3.17% of the total viable counts.

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