Effects of Heat Treatment of Hydroxyapatite on Osteoblast Differentiation
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- Asami Ayaji
- Graduate School of Oral Medicine, Matsumoto Dental University
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- Nakamura Midori
- Department of Biochemistry, Matsumoto Dental University
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- Takeuchi Mizuho
- Department of Pediatric Dentistry, Matsumoto Dental University
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- Nakayama Akira
- Department of Pediatric Dentistry, Matsumoto Dental University
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- Nakamura Hiroshi
- Department of Pediatric Dentistry, Matsumoto Dental University
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- Yoshida Takamitsu
- Department of Dental Materials, Matsumoto Dental University
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- Nagasawa Sakae
- Department of Pediatric Dentistry, Matsumoto Dental University
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- Hiraoka B. Yukihiro
- Graduate School of Oral Medicine, Matsumoto Dental University
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- Ito Michio
- Department of Dental Materials, Matsumoto Dental University
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- Udagawa Nobuyuki
- Department of Biochemistry, Matsumoto Dental University
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- Miyazawa Hiroo
- Graduate School of Oral Medicine, Matsumoto Dental University Department of Pediatric Dentistry, Matsumoto Dental University
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Abstract
To develop hydroxyapatite that promotes early cure of postoperative tissue, we heat-treated hydroxyapatite and evaluated its pH-increasing effect and Ca release. We also evaluated the effect of heat-treated hydroxyapatite on osteoblast differentiation. (1) No marked change was observed regarding the surface morphology or structure of heat-treated hydroxyapatite on SEM. (2) When hydroxyapatite was immersed in physiologic saline, the saline was made more alkaline by heat-treated than non-heat-treated hydroxyapatite. (3) When hydroxyapatite was immersed in physiologic saline, more Ca ions were released from heat-treated than non-heat-treated hydroxyapatite. (4) X-ray diffraction analysis showed a peak of CaO, which is considered to explain the Ca ion release, in heat-treated hydroxyapatite. (5) When osteoblasts were cultured with hydroxyapatite, heat-treated hydroxyapatite prevented the decrease in the number of alkaline phosphatase-positive osteoblasts in the presence of non-heat-treated hydroxyapatite. Thus, heat-treated hydroxyapatite was suggested to promote early cure of postoperative tissue. Detailed analysis of in vivo effects of heat-treated hydroxyapatite is anticipated to make its clinical application possible.
Journal
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- Journal of Hard Tissue Biology
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Journal of Hard Tissue Biology 17 (2), 37-46, 2008
THE SOCIETY FOR HARD TISSUE REGENERATIVE BIOLOGY
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Details 詳細情報について
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- CRID
- 1390001204457815552
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- NII Article ID
- 130004480472
- 40016491557
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- NII Book ID
- AA11074332
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- ISSN
- 1880828X
- 13417649
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- NDL BIB ID
- 10181343
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed