Anti-adipogenic Effects of Polyphenol Extracts of Areca Flower Tea on 3T3-L1 Preadipocytes

DOI Web Site 参考文献42件
  • Song Fei
    Coconut Research Institute, Chinese Academy of Tropical Agricultural Sciences
  • Tang MinMin
    Coconut Research Institute, Chinese Academy of Tropical Agricultural Sciences
  • Wu QiuSheng
    College of Food Science and Technology, Huazhong Agricultural University
  • Shen XiaoJun
    Coconut Research Institute, Chinese Academy of Tropical Agricultural Sciences
  • Wang Hui
    Coconut Research Institute, Chinese Academy of Tropical Agricultural Sciences
  • Chen Hua
    Coconut Research Institute, Chinese Academy of Tropical Agricultural Sciences
  • Zhao SongLin
    Coconut Research Institute, Chinese Academy of Tropical Agricultural Sciences

説明

<p>This study aimed to investigate the effects of areca flower tea polyphenol extract (AFPE) on the adipogenesis of 3T3-L1 preadipocytes. AFPE was extracted from areca flower tea using boiling water, and the polyphenolic compounds were analysed by HPLC. At doses that they did not induce cytotoxicity, AFPE (50 – 200 µg/mL) efficiently inhibited triglyceride accumulation in the mature adipocytes in a dose-dependent manner when induced to differentiate. Additionally, AFPE suppressed the secretion of leptin and the expression of lipoprotein lipase (LPL). Moreover, the anti-adipogenic properties were also attributed to the down-regulation of protein expression of major transcriptional factors in adipogenesis, including peroxisome proliferator-activated receptor γ (PPARγ) and CCAT/enhancer-binding protein α (C/EBPα). Therefore, these results suggest that AFPE may prevent obesity by inhibiting the differentiation of preadipocytes, suggesting its potential application in functional foods and nutraceuticals for obesity management.</p>

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