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- 内田 和秀
- Department of Anesthesiology, St. Marianna University School of Medicine
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- 舘田 武志
- Department of Anesthesiology, St. Marianna University School of Medicine
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- 日野 博文
- Department of Anesthesiology, St. Marianna University School of Medicine
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- 角倉 弘行
- Department of Anesthesiology, St. Marianna University School of Medicine
書誌事項
- タイトル別名
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- Nociceptive effects of pancuronium, vecuronium, atropine, and scopolamine in mice
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説明
Purpose: Nicotinic receptor agonists and muscarinic receptor agonists have been reported to produce antinociceptive effects. We hypothesized that acetylcholine receptor antagonists would decrease the pain threshold. The aim of the present study was to clarify this hypothesis with regard to drugs that are commonly used perioperatively: pancuronium, vecuronium, atropine, and scopolamine. Methods: Nociceptive effects of each drug were studied in ICR strain mice using hot-plate, acetic acid-writhing, and tail-pinch tests. Results: Hot-plate jumping latency was decreased by administration of pancuronium, but not by vecuronium. It was also decreased by higher doses of atropine and scopolamine. In the acetic acid-writhing test, four antagonists increased the frequency of writhing reactions. Conclusion: The present results suggest that antagonists of nicotinic and muscarinic receptors lower the pain threshold.
収録刊行物
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- 日本ペインクリニック学会誌
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日本ペインクリニック学会誌 10 (4), 495-500, 2003
一般社団法人 日本ペインクリニック学会
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詳細情報 詳細情報について
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- CRID
- 1390001204457953024
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- NII論文ID
- 130004239033
- 10012435047
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- NII書誌ID
- AN10440947
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- ISSN
- 18841791
- 13404903
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- NDL書誌ID
- 6756090
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可