Does long-term administration of pregabalin (without checking its efficacy) do all harm and no good?

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  • IWAMOTO Tatsushige
    Department of Anesthesiology, Kinki University Faculty of Medicine
  • SHIRAI Toru
    Department of Anesthesiology, Kinki University Faculty of Medicine
  • MORIMOTO Masahiro
    Department of Anesthesiology, Kinki University Faculty of Medicine
  • IWASAKI Shohei
    Department of Anesthesiology, Kinki University Faculty of Medicine
  • MINAMI Nahoko
    Department of Anesthesiology, Kinki University Faculty of Medicine
  • NAKAO Shinichi
    Department of Anesthesiology, Kinki University Faculty of Medicine

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Other Title
  • プレガバリンを漫然と投与していないだろうか
  • 症例 プレガバリンを漫然と投与していないだろうか
  • ショウレイ プレガバリン オ マンゼン ト トウヨ シテ イナイ ダロウ カ

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We tend to prescribe pregabalin (PGB) for patients for a long time without checking its effectiveness. In the present study, the authors investigated whether PGB administration could be stopped without any harm in 11 patients who had had PGB for 6 months or more. The experimental protocol was as follows. When we judged that a further analgesic effect of the patient would not be expected and if the patient suffered no recurring severe pain, we gradually reduced the doses of PGB. If the dose could be reduced to 25 mg, we stopped PGB administration to the patient. The results showed that PGB administration was successfully stopped for 7 patients, but could not be stopped for 4 patients. We suggested that we possibly continue unnecessary PGB administration to patients without checking its effectiveness.

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