So-called “Denture Fibroma”: A Histopathological and Immunohistochemical Study

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  • Wakami Masanobu
    Department of Crown and Bridge Prosthodontics, Nihon University School of Dentistry at Matsudo
  • Kuyama Kayo
    Department of Oral Pathology, Nihon University School of Dentistry at Matsudo Department of Diagnostic Pathology, Hospital of Nihon University School of Dentistry at Matsudo
  • Sun Yan
    Department of Oral Pathology, Nihon University School of Dentistry at Matsudo Department of Diagnostic Pathology, Hospital of Nihon University School of Dentistry at Matsudo
  • Morikawa Miyuki
    Department of Oral Pathology, Nihon University School of Dentistry at Matsudo Department of Diagnostic Pathology, Hospital of Nihon University School of Dentistry at Matsudo
  • Aida Masahiro
    Department of Crown and Bridge Prosthodontics, Nihon University School of Dentistry at Matsudo
  • Yamamoto Hirotsugu
    Department of Oral Pathology, Nihon University School of Dentistry at Matsudo Department of Diagnostic Pathology, Hospital of Nihon University School of Dentistry at Matsudo

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  • So-called "Denture Fibroma" : A Histopathological and Immunohistophemical Study
  • So-called ^|^ldquo;Denture Fibroma^|^rdquo;: A Histopathological and Immunohistochemical Study

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The purpose of this study was to investigate the histopathological and immunohistochemical characteristics of so-called “denture fibroma” and related stromal reaction. The tissues were histologically classified into inflammatory granulation type, matured fibrous type and myxoid type. Tenascin, LOX, fibrinogen and COX were strongly detected in inflammatory granulation type whereas a weak expression was detected in matured fibrous type. LOX was remarkably expressed by spindle shaped cells/fibroblastic cells and endothelial cells while tenascin was relatively expressed by monocytes in myxoid type. Despite strong expressions of tenascin, fibrinogen, COX-2 and LOX, their expressions decreased towards the deep part of the connective tissue. The greatest number of vessels was obtained in inflammatory granulation type and the least number of vessels was obtained in myxoid type which might contribute to hypoxic condition.<br>The results suggest that the so-called “denture fibroma” is a consequence of acute inflammatory reaction leading to the formation of inflammatory granulation followed by the state of fibrosis which gradually was replaced by matured collagen fibers. Furthermore, myxoid degeneration occurred when blood vessels decreased which lead to hypoxic condition.

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