Potentiation of the Antitumour Effect of Cisplatin by Administering Local Electrical Pulses to Metastatic Lesions of Hamster Oral Fibrosarcoma

DOI Web Site 被引用文献1件 参考文献31件
  • Sugita Yoshihiko
    Department of Oral Pathology, School of Dentistry, Aichi Gakuin University Center for Advanced Oral Science, Aichi Gakuin University
  • Miyamoto Yuji
    Department of Oral Pathology, School of Dentistry, Aichi Gakuin University
  • Anuudari Erkhembaatar
    Department of Oral Pathology, School of Dentistry, Aichi Gakuin University
  • Torii Ryota
    Department of Oral Pathology, School of Dentistry, Aichi Gakuin University
  • Kato Seeta
    Department of Oral Pathology, School of Dentistry, Aichi Gakuin University
  • Kawai Ryoko
    Department of Oral Pathology, School of Dentistry, Aichi Gakuin University
  • Yoshida Waka
    Department of Oral Pathology, School of Dentistry, Aichi Gakuin University Center for Advanced Oral Science, Aichi Gakuin University
  • Sato Emiko
    Department of Oral Pathology, School of Dentistry, Aichi Gakuin University Center for Advanced Oral Science, Aichi Gakuin University
  • Kubo Katsutoshi
    Department of Oral Pathology, School of Dentistry, Aichi Gakuin University Center for Advanced Oral Science, Aichi Gakuin University
  • Ohno Yuzo
    Medical Corporate Group KOFUKAI
  • Maeda Hatsuhiko
    Department of Oral Pathology, School of Dentistry, Aichi Gakuin University Center for Advanced Oral Science, Aichi Gakuin University

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Electrochemotherapy (ECT) is currently receiving much attention as a method that can enhance the delivery of antitumour drugs into tumour cells by electroporation. In this study, we examined the effect of cisplatin on metastatic lesions of hamster oral fibrosarcoma by administering it in association with low-voltage electrical pulses. Oral fibrosarcoma was transplanted submucosally into the cheek pouches of 80 hamsters. After transplantation, when the diameter of the metastatic lesion in the left submandibular lymph node had reached 100 mm3, the hamsters were divided into four groups: D+E+ group (cisplatin treatment followed by electroporation; D+E- group (cisplatin treatment); D-E+ group (electroporation without cisplatin treatment); and D-E- group (no treatment). The antitumour effect of cisplatin was marked in the D+E+ group and the metastatic lesion disappeared in some of the animals. These results showed that when ECT consisting of cisplatin plus low-voltage electroporation was applied to metastatic tumour lesions, the antitumour effect of the drug on the lesions was enhanced. Therefore, ECT would seem to be a highly-safe new method that may be of use in the treatment of metastatic tumours.

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