Changes in Metallothionein Isoform Expression in the Bones of Ovariectomized Rats

DOI Web Site Web Site 参考文献28件
  • Sogawa Chiharu
    Department of Dental Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Advanced Research Center for Oral and Craniofacial Sciences, Okayama University Dental School
  • Ikegame Mika
    Department of Oral Morphology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Advanced Research Center for Oral and Craniofacial Sciences, Okayama University Dental School
  • Miyazaki Ikuko
    Department of Brain Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
  • Ara Toshiaki
    Department of Dental Pharmacology, Matsumoto Dental University School of Dentistry Department of Hard Tissue Research, Matsumoto Dental University Graduate School of Oral Medicine
  • Imamura Yasuhiro
    Department of Dental Pharmacology, Matsumoto Dental University School of Dentistry Department of Hard Tissue Research, Matsumoto Dental University Graduate School of Oral Medicine
  • Okusha Yuka
    Department of Dental Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
  • Ohyama Kazumi
    RI Research Center, Okayama University Dental School
  • Asanuma Masato
    Department of Medical Neurobiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
  • Sogawa Norio
    Department of Dental Pharmacology, Matsumoto Dental University School of Dentistry Department of Hard Tissue Research, Matsumoto Dental University Graduate School of Oral Medicine
  • Yamamoto Toshio
    Department of Oral Morphology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
  • Kozaki Ken-ichi
    Department of Dental Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

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Metal-binding proteins, metallothioneins (MTs), may play important roles in bone metabolism. However, the contribution of MTs to bone metabolism remains obscure. In the present study, we investigated the expression of MT isoforms in bone cells and mRNA for MT isoforms in the tibiae following ovariectomy (OVX). The results obtained showed that MT-I/II and MT-III were expressed in osteoblasts, osteoclasts, and osteocytes 4 weeks after OVX. Peaks in the mRNA expression ratios (OVX/Sham) of MT-I/II and MT-III changed following OVX. The expression ratio of MT-I/II increased after 1 week, whereas that of MT-III increased 4 weeks after OVX. These results suggest that the contribution of MTs to bone metabolism may depend on the isoforms in the cell types and the stage after OVX.

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