Effect of Capsaicin Cream on Neuropathic Pain

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Other Title
  • 神経因性疼痛に対するカプサイシン軟膏の効果

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Objective: The aim of this study was to evaluate whether 0.05% capsaicin cream could alleviate neuropathic pain that was unresponsive to conventional treatment. The changes of sleep, spirit, and activities of daily living, and side effects during capsaicin treatment were also studied.<br>Patients and methods: Capsaicin cream was applied to 12 patients: six with postherpetic neuralgia (PHN) and six with pain following nerve injury. The intensity of pain before, during, and after capsaicin treatment was measured by Visual Analogue Scale (VAS: 0=no pain, 100=severe pain).<br>Results: Median VAS scores before, during, and after treatment were 45, 10, and 10, respectively, for the PHN group, and 80, 40, and 50, respectively, for the nerve injury group. In both groups, median VAS scores were significantiy lower (p<0.05) during and after the treatment than those before treatment. Sleep, spirit, and activities of daily living were improved in 42%, 75%, and 58% of patients, respectively, during treatment. No severe side effects, except skin exfoliation in one patient, were observed. After capsaicin treatment, the pain recurred slowly but not significantly in the nerve injury group. No recurrence of pain was observed in the PHN group.<br>Conclusions: Our findings suggest that capsaicin cream is effective for treatment of neuropathic pain due to PHN and nerve injury.

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Details 詳細情報について

  • CRID
    1390001204458605824
  • NII Article ID
    130004085924
  • DOI
    10.11321/jjspc1994.6.26
  • ISSN
    18841791
    13404903
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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