A Volume Evaluation of Dental Caries in a Mouse with the Use of the Micro-CT Scan

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  • Shimoda Shinji
    Department of Oral Anatomy, Tsurumi University, School of Dental Medicine
  • Ohta Masumi
    Department of Pediatric Dentistry, Tsurumi University, School of Dental Medicine
  • Mohideen Yumna
    Department of Oral Anatomy, Tsurumi University, School of Dental Medicine
  • Ohshima Tomoko
    Department of Oral Microbiology, Tsurumi University, School of Dental Medicine
  • Maeda Nobuko
    Department of Oral Microbiology, Tsurumi University, School of Dental Medicine
  • Kawasaki Kenzo
    Department of Oral Anatomy, Tsurumi University, School of Dental Medicine
  • Asada Yoshinobu
    Department of Pediatric Dentistry, Tsurumi University, School of Dental Medicine

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Abstract

The purpose of this study is to develop a three-dimensional method of caries evaluation; once a method is established genetic variables can be altered in order to detect the gene(s) involved in the development of dental caries in mice. As dental caries has a three-dimensional nature to its course, the Micro-CT scan quantifies the volume of caries. Inbred Mice were used of known caries susceptibility —BALB/c mice. Mice were divided into the control and experimental group; later inoculated with Streptococcus mutans. The experimental group was fed a caries promoting diet and later caries volume was evaluated by use of the Micro-CT scan in both groups. There was a clear difference in tooth volume of mice infected for 7 weeks and 9 weeks, the Micro-CT scan indicated this evidently.

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