Specific Metallization of Double-Stranded DNA Using Reducing Group-Labeled Intercalator

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  • Himuro Takahiro
    Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology
  • Araki Ryo
    Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology
  • Sato Shinobu
    Graduate School of Engineering, Kyushu Institute of Technology
  • Takenaka Shigeori
    Graduate School of Engineering, Kyushu Institute of Technology
  • Yasuda Takashi
    Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology

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  • 還元基修飾インターカレータを用いた2本鎖DNAの特異的金属被覆
  • カンゲンキ シュウショク インターカレータ オ モチイタ 2ホン サ DNA ノ トクイテキ キンゾク ヒフク

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Abstract

<p>We demonstrated that the DNA metallization technique using reducing group-labeled intercalator molecules permits dsDNA (double-stranded DNA) molecules to be specifically metallized while not permitting metallization of ssDNA (single-stranded DNA) molecules. First, dsDNA and ssDNA molecules were stretched on a mica surface using spin-coating technique, and metallization process was conducted. AFM observation showed that only dsDNA molecules were metallized, resulting in formation of nanowires with a diameter of about 11 nm. Secondly, dsDNA and ssDNA molecules were stretched and immobilized between two microelectrodes. Impedance analysis showed that the electrical conductivity of only dsDNA was drastically increased after the metallization process.</p>

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