Development of a Body-on-a-Chip Using 3-D Microstructuring Technique

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  • Kato Yoshiki
    Department of Micro Engineering, Kyoto University
  • Hirai Yoshikazu
    Department of Micro Engineering, Kyoto University Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University
  • Kamei Ken-ichiro
    Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University
  • Tsuchiya Toshiyuki
    Department of Micro Engineering, Kyoto University
  • Tabata Osamu
    Department of Micro Engineering, Kyoto University

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  • 3次元微細加工を応用したBody on a Chipの開発
  • 3ジゲン ビサイ カコウ オ オウヨウ シタ Body on a Chip ノ カイハツ

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Abstract

In vitro cell-based assay with human cells is getting attention since the accuracy of preclinical predictions of drug responses should be improved to reducing costly failures in clinical trials. In order to generate reliable predictions, we present a micro-engineered biomimetic systems “Body-on-a-Chip”, to investigate the effects of drugs/metabolites on various organs by assembling a closed-loop medium circulation system on one microfluidic device. For three-dimensional (3-D) polymeric device fabrication, an advanced 3-D lithography with the process optimization method is applied to improve the current soft-lithography technique. Our Body-on-a-Chip is successfully applied to evaluate the effect of an anti-cancer drug (doxorubicin) on cell survival of human heart and liver cells.

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