Highly-sensitive Detection of Adenine Molecule using Surface-Enhanced Raman Spectroscopy with Gold Nanoparticle Dimer Array
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- Aiba Kiyohito
- Department of Mechanical Engineering, Graduate Scool of Engineering, Kobe University
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- Ikegami Kohei
- Department of Mechanical Engineering, Graduate Scool of Engineering, Kobe University
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- Yamazaki Shin-nosuke
- Department of Mechanical Engineering, Graduate Scool of Engineering, Kobe University
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- Sugano Koji
- Department of Mechanical Engineering, Graduate Scool of Engineering, Kobe University
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- Isono Yoshitada
- Department of Mechanical Engineering, Graduate Scool of Engineering, Kobe University
Bibliographic Information
- Other Title
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- 金ナノ粒子二量体配列を用いたアデニン分子の高感度表面増強ラマン分光検出
- キン ナノ リュウシ ニリョウタイ ハイレツ オ モチイタ アデニン ブンシ ノ コウカンド ヒョウメン ゾウキョウ ラマン ブンコウ ケンシュツ
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Abstract
This paper reports on highly-sensitive adenine molecule detection by surface enhanced Raman spectroscopy with single molecule sensitivity using directionally and regularly arrayed gold nanoparticle dimers with the diameter of 100 nm on the substrate. A particle dimer shows huge electromagnetic enhancement when particle connection direction is matched to polarization direction of light. In this study the dimers were arrayed by the nanotrench-guided self-assembly for generating huge total Raman enhancement. The fabricated structures were used for adenine molecule detections of 10-11 M aqueous solutions. We successfully detected the molecules at the ultra-low concentration, which indicates single molecule sensitivity. The concentration limit of detection had previously been 10-8 M in the reported literatures, which used the simple method with the prefabricated SERS substrate. Our developed substrate exhibited 103 times sensitivity. The clear peaks were found at the integration time of 0.1 s. We confirmed that our developed SERS substrate enables us to detect adenine molecules with high sensitivity and short integration time.
Journal
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- IEEJ Transactions on Sensors and Micromachines
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IEEJ Transactions on Sensors and Micromachines 136 (6), 256-260, 2016
The Institute of Electrical Engineers of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390001204462546688
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- NII Article ID
- 130005154789
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- NII Book ID
- AN1052634X
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- ISSN
- 13475525
- 13418939
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- NDL BIB ID
- 027489742
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed