Bioactive Compounds from the Leaves of Lumnitzera racemosa against Acetaminophen-induced Liver damage in vitro

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  • DARWISH Ahmed Gomaa Gomaa
    Department of Biochemistry, Faculty of Agriculture, Minia University Department of Pharmacognosy, Graduate School of Biomedical and Health Sciences, Hiroshima University
  • SAMY Mamdouh Nabil
    Department of Pharmacognosy, Faculty of Pharmacy, Minia University
  • SUGIMOTO Sachiko
    Department of Pharmacognosy, Graduate School of Biomedical and Health Sciences, Hiroshima University
  • OTSUKA Hideaki
    Department of Pharmacognosy, Graduate School of Biomedical and Health Sciences, Hiroshima University Department of Natural Products Chemistry, Faculty of Pharmacy, Yasuda Women’s University
  • ABDEL-SALAM Hosni
    Department of Biochemistry, Faculty of Agriculture, Minia University
  • ISSA Mohammady Ibrahim
    Department of Biochemistry, Faculty of Agriculture, Minia University
  • SHAKER Emad Sabry
    Department of Biochemistry, Faculty of Agriculture, Minia University
  • MATSUNAMI Katsuyoshi
    Department of Pharmacognosy, Graduate School of Biomedical and Health Sciences, Hiroshima University

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タイトル別名
  • Bioactive Compounds from the Leaves of <i>Lumnitzera racemosa</i> against Acetaminophen-induced Liver damage <i>in vitro</i>

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<p>Phytochemical investigation of the mangrove plant Lumnitzera racemosa WILLD (Fam: Combretaceae) has resulted in the isolation of 8 compounds by various chromatographic techniques (silica gel, ODS column chromatography and HPLC). The structures of these compounds were determined by spectrometric analysis (UV, IR, HR-ESI-MS, 1D and 2D-NMR). All the isolated compounds were evaluated for their hepatoprotective activity. The Compound number 8 showed high hepatoprotective activity against acetoaminophen and compound 1 showed moderate activity compared to glycyrrhizin as the positive control using human Hep G2 cell line. The Compounds number 2, 3, 4, 5, 6 and 8 showed the highest DPPH radical scavenging activity (IC50: 14.74±5.66, 18.88±3.56, 5.93±2.1, 7.17±0.42, 7.38±1.03 and 15.72±1.18 µM, respectively), while compounds 1 and 7 showed lowest DPPH radical scavenging activity comparable with the standard trolox (IC50: 5.93±2.19 μM).</p>

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  • 沙漠研究

    沙漠研究 26 (3), 183-186, 2016

    日本沙漠学会

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