Antifungal Characteristics of N,N'-Hexamethylenebis(4-carbamoyl-1-decylpyridinium bromide)

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  • OKAZAKI KIYO
    Faculty of Human Life Science, Shikoku University
  • YOSHIDA MUNEHIRO
    Takamatsu Works, lnui Corporation
  • MAYAMA MARI
    Faculty of Human Life Science, Shikoku University
  • SHIRAI AKIHIRO
    Department of Biological Science and Technology, Faculty of Engineering, The University of Tokushima
  • MAEDA TAKUYA
    Department of Biological Science and Technology, Faculty of Engineering, The University of Tokushima
  • NAGAMUNE HIDEAKI
    Department of Biological Science and Technology, Faculty of Engineering, The University of Tokushima
  • KOURAI HIROKI
    Department of Biological Science and Technology, Faculty of Engineering, The University of Tokushima

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Description

A bis-quaternary ammonium compound (bis-QAC), N, N'-hexamethylenebis (4-carbamoyl-1-decylpyridinium bromide) (D-38), exhibited a wide antifungal spectrum and a strong activity against sixteen strains of fungi including nine strains isolated from various kinds of food. The antifungal activity was higher than that of N-dodecylpyridinium iodide, a typical mono-QAC, and that of the commonly used fungicide, 2-(4-thiazolyl) benzimidazole. The activity of D-38, however, was comparatively low when it was measured by the agar dilution method. It is considered that the hydrophobic D-38 molecules, having two long alkyl chains, interacted with the agar medium, and therefore showed lower activity results. On the other hand, the activity of D-38 against Aspergillus niger IFO 6342 was not significantly influenced by temperature, pH and the initial spore concentration. These results indicate that bis-QACs can exhibit a high antifungal activity whether or not the environmental conditions change.

Journal

  • Biocontrol Science

    Biocontrol Science 11 (1), 37-42, 2006

    The Society for Antibacterial and Antifungal Agents, Japan

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