n-3系列多価不飽和脂肪酸強化食のアトピー性皮膚炎に対する効果

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タイトル別名
  • THE EFFECTS OF DIETARY SUPPLEMENTATION WITH n-3 POLYUNSATURATED FATTY ACIDS (n-3 PUFA) ON ATOPIC DERMATITIS
  • A MULTICENTER PLACEBO CONTROLLED TRIAL USING n-3 PUFA ENRICHED FOOD (IPAOLE)
  • n-3系列多価不飽和脂肪酸強化食品イパオールを用いた多施設 placebo controlled cross over trial による検討

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説明

In a multi-center placebo controlled cross over trial, We compared the efficacy of continuous n-3 PUFA enriched food “Ipaole” supplementation (daily intake dose; ALA: 60mg/kg, EPA: 30mg/kg, DHA: 18mg/kg) for atopic dermatitis to that of a isonergic placebo containing olive oil for 4 weeks.<br>A total of 37 patients with atopic dermatitis, aged 12.8+4.9 years, from 6 investigative centers (male: 17, female: 20; severe: 22, moderate: 15) were employed.<br>The patients were randomly divided into two groups: A group consists of 20 patients receiving Ipaole preceding placebo; B group 17 patients receiving placebo preceding Ipaole.<br>Of the 37 patients who started the trial 2 from A group and 2 from B group dropped out.<br>During Ipaole supplementation a statistically significant improvement was observed in the overall severity and grade of inflammation, and in the percentage of the body surface involved by ezema (p<0.01).<br>But during placebo administration no significant reduction of symptom score was shown. During Ipaole supplementation the treatment score also significantly decreased (p<0.1) but does not significantly reduced during placebo intake.<br>During Ipaole supplementation a statistically significant rise of EPA, EPA/AA and DHA of serum phospholipids was observed (p<0.001, p<0.01), but not observed during placebo intake.<br>Bleeding time prolonged slightly in some patients, but any clinical sign of bleeding was not observed.<br>These results suggest that the supplementation of n-3 PUFA enriched food is useful in the treatment of some patients with atopic dermatitis.

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詳細情報 詳細情報について

  • CRID
    1390001204473808256
  • NII論文ID
    130004370929
  • DOI
    10.3388/jspaci.9.67
  • ISSN
    18822738
    09142649
  • データソース種別
    • JaLC
    • Crossref
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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