Role of intestinal Bifidobacteria in the development of allergic disease: effects of prebiotic oligosaccharides on atopic infants
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- Shibata Rumiko
- Department of Pediatrics, Fukuoka National Hospital
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- Koga Yasuhiro
- Laboratory for Infectious Diseases, Tokai University School of Medicine
Bibliographic Information
- Other Title
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- アレルギー疾患発症における腸内細菌ビフィズス菌の役割―乳幼児アトピー性皮膚炎におけるオリゴ糖のプレバイオティクス効果
Description
Background: The increase in allergic diseases is attributed to a relative lack of microbial stimulation of the infantile gut immune system. There have been attempts to probiotics for the treatment or prevention of atopic dermatitis. Recently a mixture of prebiotic oligosaccharides in atopic risk infants reduced the incidence of AD and increased fecal bifidobacteria. A prebiotic is a non-digestible food ingredient that beneficially affects the host by selectively stimulating the growth of bifidobacteria in the gut. Objective: A randomizedcontrolled trial (RCT) was conducted to confirm the therapeutic effect of kestose fructo-oligo saccharide on AD. Methods: In 34 AD (aged 6 to 36 months) with food allergy, fecal flora and AD severity were analyzed. In preliminary open pilot study, 12 AD infants with the low number of fecal bifidobacteria were received kestose supplements for12 weeks. The RCT of kestose was carried out in 29 AD children with food allergy aged 6 to 46 months (mean 17 months). One to 2 g kestose as active and maltose as placebo were given every day for 12 weeks. Clinical evaluation of AD severity (SCORAD), serum total IgE, specific IgE (Immuno-CAP) and enumeration of bifidobacteria in the feces using realtime PCR were performed at Weeks 0, 6, and 12. Results: Bifidobacteria of feces were decreased in severe AD children. There was a significant correlation between the bifidobacteria count and severity score. In RCT, SCORAD score significantly decreased in active group. Bifidobacteria count of feces were increased in active group in cases with low bifudobacteria. There were no changes in total IgE and specific IgE levels to mite, egg and milk. Conclusion: Although the mechanism of this effect requires further investigation, it appears likely that kestose oligosaccharides modulate altering bowel flora and may also be directly modulate the intestinal permeability.<br>
Journal
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- Nihon Shoni Arerugi Gakkaishi. The Japanese Journal of Pediatric Allergy and Clinical Immunology
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Nihon Shoni Arerugi Gakkaishi. The Japanese Journal of Pediatric Allergy and Clinical Immunology 26 (1), 99-104, 2012
THE JAPANESE SOCIETY OF PEDIATRIC ALLERGY AND CLINICAL IMMUNOLOGY
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Details 詳細情報について
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- CRID
- 1390001204474965120
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- NII Article ID
- 130004504296
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- ISSN
- 18822738
- 09142649
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed
