Innate immune responses in allergy
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- Yoshimoto Tomohiro
- Laboratory of Allergic Diseases, Institute for Advanced Medical Sciences, Hyogo College of Medicine
Bibliographic Information
- Other Title
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- アレルギーにおける自然免疫応答
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Abstract
We proposed two types of allergic response: IgE-dependent and IgE-independent, and designate these as 'acquired-type allergy' and 'innate-type allergy', respectively. IL-18 and IL-33 are essential regulators for 'innate-type allergy'. Especially, IL-33 stimulates both innate (basophils, mast cells, or group 2 innate lymphoid cells) and acquired (Th2 cells) allergy-related cells to induce and/or augment Th2 cytokine production, which leads to eosinophilic inflammation in vivo. Thus, IL-33 is an essential regulator for both 'innate-type allergy' and 'acquired-type allergy', and might be a therapeutic target for allergic diseases.<br>
Journal
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- Nihon Shoni Arerugi Gakkaishi. The Japanese Journal of Pediatric Allergy and Clinical Immunology
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Nihon Shoni Arerugi Gakkaishi. The Japanese Journal of Pediatric Allergy and Clinical Immunology 27 (5), 665-673, 2013
THE JAPANESE SOCIETY OF PEDIATRIC ALLERGY AND CLINICAL IMMUNOLOGY
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Details 詳細情報について
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- CRID
- 1390001204474966144
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- NII Article ID
- 130004504350
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- ISSN
- 18822738
- 09142649
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed