Dietary Intake of Vitamin B6 and Risk of Breast Cancer in Taiwanese Women

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  • Chou Yu-Ching
    School of Public Health, National Defense Medical Center
  • Chu Chi-Hong
    Department of Surgery, Tri-Service General Hospital
  • Wu Mei-Hsuan
    Department of Public Health, College of Medicine, Fu-Jen Catholic University
  • Hsu Giu-Cheng
    Department of Radiology, Tri-Service General Hospital
  • Yang Tsan
    Department of Health Business Administration, Meiho University
  • Chou Wan-Yun
    Department of Public Health, College of Medicine, Fu-Jen Catholic University
  • Huang Hsin-Ping
    School of Public Health, National Defense Medical Center
  • Lee Meei-Shyuan
    School of Public Health, National Defense Medical Center
  • Yu Cheng-Ping
    Department of Pathology, Tri-Service General Hospital
  • Yu Jyh-Cherng
    Department of Surgery, Tri-Service General Hospital
  • Sun Chien-An
    Department of Public Health, College of Medicine, Fu-Jen Catholic University

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Background: B vitamins, including vitamin B6, are coenzymes that are important for DNA integrity and stability. Deficiencies in B vitamins may promote tumor carcinogenesis.<BR>Methods: We examined the association of dietary vitamin B6 intake with overall breast cancer risk and breast cancers stratified by hormone receptor status. This case-control study included 391 breast cancer cases and 782 control subjects enrolled at the Tri-Service General Hospital in Taipei, Taiwan. Energy-adjusted intake of vitamin B6 was derived from a food frequency questionnaire. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression.<BR>Results: As compared with women in the lowest tertile, the multivariate-adjusted ORs for breast cancer among women in the second and highest tertiles of vitamin B6 intake were 0.78 (95% CI, 0.64–2.52) and 0.64 (0.26–0.92), respectively. In addition, higher vitamin B6 intake was associated with a significantly lower risk of developing ER-negative breast tumors.<BR>Conclusions: Our findings suggest that higher intake of vitamin B6 is associated with a reduction in breast cancer risk, particularly ER-negative tumors.

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