Safety of baby food containing ovomucoid-reduced egg white for atopic dermatitis infants and children without previous egg white exposure

DOI Web Site 10 References
  • Inuo Chisato
    Department of Pediatrics, School of Medicine, Fujita Health University Department of Pediatrics, Banbuntane hotokukai Hospital, Fujita Health University
  • Mori Yuji
    Department of Pediatrics, School of Medicine, Fujita Health University
  • Kondo Yasuto
    Department of Pediatrics, Banbuntane hotokukai Hospital, Fujita Health University
  • Tanaka Kenichi
    Department of Pediatrics, Banbuntane hotokukai Hospital, Fujita Health University
  • Nakajima Yoichi
    Department of Pediatrics, Banbuntane hotokukai Hospital, Fujita Health University
  • Kawai Manabu
    Department of Pediatrics, School of Medicine, Fujita Health University
  • Yamawaki Kazuo
    Department of Pediatrics, Banbuntane hotokukai Hospital, Fujita Health University
  • Kimura Mamoru
    R & D Division, Kewpie Corporation
  • Tsuge Ikuya
    Department of Pediatrics, School of Medicine, Fujita Health University
  • Urisu Atsuo
    Department of Pediatrics, Banbuntane hotokukai Hospital, Fujita Health University

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Other Title
  • 卵白未摂取アトピー性皮膚炎乳幼児に対するオボムコイド減量加熱全卵ベビーフードの安全性

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<p> Background : Infants with atopic dermatitis have a high risk of having egg allergy. In this study, safety of baby food containing ovomucoid-reduced egg white for infants and children with atopic dermatitis was evaluated.</p><p> Methods : Using a bottle of baby food containing ovomucoid-reduced egg white, an open oral food challenge test was conducted on infants and children with atopic dermatitis and without previous exposure to egg white.</p><p> Results : Forty-six subjects [24 boys, 22 girls ; median age 10.0 months (9-12 months) ] were included in the study. The median egg white-specific IgE levels (10.1 UA/ml), median ovomucoid-specific IgE levels (0.21 UA/ml), and median serum thymus and activation-regulated chemokine (1553 pg/ml) were examined. Forty-three subjects (93.4%) could ingest a complete bottle of baby food without any allergic reactions. Although three subjects displayed a slight skin symptom, they could ingest a complete bottle of baby food without any symptoms in a retest.</p><p> Conclusion : It is suggested that baby food containing ovomucoid-reduced egg white is safe for infants and children with atopic dermatitis. The oral food challenge test for infants and children with high levels of ovomucoid-specific IgE needs to be conducted in the future.</p>

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