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The differential diagnosis of food protein-induced enteropathy by intestinal mucosal pathology
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- Kudo Takahiro
- Department of Pediatrics, Juntendo University Faculty of Medicine
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- Oka Itsuhiro
- Department of Pediatrics, Juntendo University Faculty of Medicine
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- Arai Nobuyasu
- Department of Pediatrics, Juntendo University Faculty of Medicine
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- Kyodo Reiko
- Department of Pediatrics, Juntendo University Faculty of Medicine
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- Sato Masamichi
- Department of Pediatrics, Juntendo University Faculty of Medicine
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- Miyata Eri
- Department of Pediatrics, Juntendo University Faculty of Medicine
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- Hosoi Kenji
- Department of Pediatrics, Juntendo University Faculty of Medicine
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- Matsumura Seiichi
- Department of Pediatrics, Juntendo University Faculty of Medicine
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- Obayashi Naho
- Department of Pediatrics, Juntendo University Faculty of Medicine
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- Ikuse Tamaki
- Department of Pediatrics, Juntendo University Faculty of Medicine
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- Jimbo Keisuke
- Department of Pediatrics, Juntendo University Faculty of Medicine
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- Mori Mari
- Department of Pediatrics, Juntendo University Faculty of Medicine
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- Aoyagi Yo
- Department of Pediatrics, Juntendo University Faculty of Medicine
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- Fujii Tohru
- Department of Pediatrics, Juntendo University Faculty of Medicine
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- Ohtsuka Yoshikazu
- Department of Pediatrics, Juntendo University Faculty of Medicine
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- Shimizu Toshiaki
- Department of Pediatrics, Juntendo University Faculty of Medicine
Bibliographic Information
- Other Title
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- 消化管病理からの鑑別診断
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Description
<p> Food protein-induced enteropathy is one of non-IgE-mediated food allergies and develops in infants within 1-year-old, with prolonged diarrhea, vomits, bloody stools, abdominal distention, and if severe malnutrition, failure to thrive and developmental retardation. It is often difficult to diagnose as this disease, therefore early diagnosis and early intervention are important.</p><p> Although the food loading test is the basis for the diagnosis of this, as an objective test, the antigen specific lymphocyte stimulation test on the food antigen is useful for identifying the causative antigen. In endoscopic examination of gastrointestinal tract, inflammatory findings are recognized in the duodenum and colonic mucosa. In pathological examination from mucosal biopsy, inflammatory cell infiltration such as eosinophils and lymphocytes is noticed. Furthermore, food protein induced enteropathy that exhibits malabsorption and failure to thrive evaluates villous atrophy and crypt hyperplasia in duodenal mucosa.</p><p> Since many diseases causing chronic diarrhea exist other than food protein-induced enteropathy, confirming the findings of the gastrointestinal mucosa using endoscopic and histopathological examination helps not only diagnosis, but also indicators for starting enteral nutrition. Therefore, it should be considered to perform the endoscopic examination when food protein-induced enteropathy is suspected.</p>
Journal
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- Nihon Shoni Arerugi Gakkaishi. The Japanese Journal of Pediatric Allergy and Clinical Immunology
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Nihon Shoni Arerugi Gakkaishi. The Japanese Journal of Pediatric Allergy and Clinical Immunology 31 (1), 7-12, 2017
THE JAPANESE SOCIETY OF PEDIATRIC ALLERGY AND CLINICAL IMMUNOLOGY
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Details 詳細情報について
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- CRID
- 1390001204475576064
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- NII Article ID
- 130005519728
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- ISSN
- 18822738
- 09142649
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
- OpenAIRE
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- Abstract License Flag
- Disallowed