Photodynamic Therapy in Combination with Porfimer Sodium and a Novel Diode Laser Device

DOI
  • OURA Takehiro
    Department of Dentistry and Oral and Maxillofacial Surgery, Hamamatsu University School of Medicine
  • TANAKA Hideo
    Department of Dentistry and Oral and Maxillofacial Surgery, Hamamatsu University School of Medicine
  • KATOU Fuminori
    Department of Dentistry and Oral and Maxillofacial Surgery, Hamamatsu University School of Medicine
  • HASHIMOTO Kenji
    Department of Dentistry and Oral and Maxillofacial Surgery, Hamamatsu University School of Medicine

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Other Title
  • ポルフィマーナトリウムと新規半導体レーザーの組み合わせによる光線力学療法

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Abstract

Photodynamic therapy (PDT) is a treatment modality that utilizes photosensitizer activated by laser light, having the advantage of selective destruction of malignant tumor cells. However, the conventional dye laser used for PDT, such as the excimer dye laser system, is too large and costly. We developed a diode laser device, which is small, lightweight and easy to use, for PDT in combination with porfimer sodium and estimated its efficacy in tumor models. As a result, necrosis to a depth of about 10mm was obtained. This novel laser device may help expand the clinical applications of PDT.

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