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Measurement of specific IgE antibody to Ara h 2 and its usefulness as a diagnostic tool for peanut allergy
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- Ebisawa Motohiro
- Clinical Research Center for Allergology and Rheumatology, Sagamihara National Hospital
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- Ito Komei
- Department of Allergy, Aichi Children's Health and Medical Center
Bibliographic Information
- Other Title
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- ピーナッツアレルギー診断におけるAra h 2特異的IgE抗体測定の意義
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Description
Objective<br> The purpose of this study is to document clinical utility of measurement of specific IgE antibody to Ara h 2 (Ara h 2-IgE) for diagnosis of peanut allergy in Japanese children.<br> Methods<br> One hundred and fifty two children were included having a suspicion of peanut allergy (peanut allergy: PA n=68, non-peanut allergy: NPA n=84). Specific IgE antibodies to five allergen components from peanut in the sera from those subjects were measured by ImmunoCAP®.<br> Results<br> Ara h 2-IgE was the best for diagnosis of peanut allergy. The specific IgE titer of 95% PPV was 4.71 UA/ml. Sensitivity at that IgE titer was 57.4%. For specific IgE antibody to crude peanut extract (f13-IgE), sensitivity at 50.8 UA/ml (95% PPV) was 20.6% and that at 14.0 UA/mL, which was the decision point for 95% PPV reported by Sampson, was 36.8%, respectively. NPV of Ara h 2-IgE at the existing cut off (0.35 UA/ml) was 89.3% regardless of specific IgE titer of f13.<br> Conclusion<br> The measurement of Ara h 2-IgE combined with f13-IgE is accurate for diagnosis of peanut allergy and is useful in order to decrease the number of peanut challenges at the clinic.<br>
Journal
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- Nihon Shoni Arerugi Gakkaishi. The Japanese Journal of Pediatric Allergy and Clinical Immunology
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Nihon Shoni Arerugi Gakkaishi. The Japanese Journal of Pediatric Allergy and Clinical Immunology 27 (4), 621-628, 2013
THE JAPANESE SOCIETY OF PEDIATRIC ALLERGY AND CLINICAL IMMUNOLOGY
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Details 詳細情報について
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- CRID
- 1390001204476294784
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- NII Article ID
- 130004504348
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- ISSN
- 18822738
- 09142649
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed