Measurement of specific IgE antibody to Ara h 2 and its usefulness as a diagnostic tool for peanut allergy

  • Ebisawa Motohiro
    Clinical Research Center for Allergology and Rheumatology, Sagamihara National Hospital
  • Ito Komei
    Department of Allergy, Aichi Children's Health and Medical Center

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Other Title
  • ピーナッツアレルギー診断におけるAra h 2特異的IgE抗体測定の意義

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Description

Objective<br> The purpose of this study is to document clinical utility of measurement of specific IgE antibody to Ara h 2 (Ara h 2-IgE) for diagnosis of peanut allergy in Japanese children.<br> Methods<br> One hundred and fifty two children were included having a suspicion of peanut allergy (peanut allergy: PA n=68, non-peanut allergy: NPA n=84). Specific IgE antibodies to five allergen components from peanut in the sera from those subjects were measured by ImmunoCAP®.<br> Results<br> Ara h 2-IgE was the best for diagnosis of peanut allergy. The specific IgE titer of 95% PPV was 4.71 UA/ml. Sensitivity at that IgE titer was 57.4%. For specific IgE antibody to crude peanut extract (f13-IgE), sensitivity at 50.8 UA/ml (95% PPV) was 20.6% and that at 14.0 UA/mL, which was the decision point for 95% PPV reported by Sampson, was 36.8%, respectively. NPV of Ara h 2-IgE at the existing cut off (0.35 UA/ml) was 89.3% regardless of specific IgE titer of f13.<br> Conclusion<br> The measurement of Ara h 2-IgE combined with f13-IgE is accurate for diagnosis of peanut allergy and is useful in order to decrease the number of peanut challenges at the clinic.<br>

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Details 詳細情報について

  • CRID
    1390001204476294784
  • NII Article ID
    130004504348
  • DOI
    10.3388/jspaci.27.621
  • ISSN
    18822738
    09142649
  • Text Lang
    ja
  • Data Source
    • JaLC
    • Crossref
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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