Photo-thermal therapy of Laser and Electromagnetic Waves : with histo-diffluence & histo-evaporation

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  • MATSUURA Hiroyuki
    Department of Geron-technology, National Center for Geriatrics and Gerontology, Department of Geron-technology
  • NAKANO Masahiro
    University of Occupational and Environmental Health
  • NODA Nobuo
    Department of Geron-technology, National Center for Geriatrics and Gerontology, Department of Geron-technology
  • KOIDE Kazuharu
    Department of Geron-technology, National Center for Geriatrics and Gerontology, Department of Geron-technology
  • ITO Yasumi
    Department of Geron-technology, National Center for Geriatrics and Gerontology, Department of Geron-technology
  • NEMOTO Tetsuya
    Department of Geron-technology, National Center for Geriatrics and Gerontology, Department of Geron-technology

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Other Title
  • 組織融解や蒸発現象を伴うレーザー・光線力学療法の基礎理論
  • ソシキ ユウカイ ヤ ジョウハツ ゲンショウ オ トモナウ レーザー コウセン リキガク リョウホウ ノ キソ リロン

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We proposed fundamental relations between an exposure of electromagnetic waves and temperatures of irradiated tissues, in the case of arising the histo-diffluence or the histo-evaporation of the target tissue Under irradiation for the target tissues, we see they have an increasing in temperature. However, the increasing of temperature are depressed by diffluence or evaporation of the tissues, i.e., what we call, by specific latent heat. We think that the solidification point of tissue is -10℃, and that boiling point is 120℃, since the target tissues have much tissue fluid. Then we hypothesize the coefficient of thermal conductivity to be 10^<-3>cal s^<-1>cm^<-1> and irradiation energies of Laser to have 1000mW/cm^2s, we can melt the regions of 0.65cm at tissue's depth. If the tissue and its fluid have the specific heat 1.0cal/g.deg, specific latent heat of the melting point 80cal/deg, and that of the boiling point 539cal/deg, the velocity of backward movement for the histoevaporation surface about reaches to 3.5×10^<-6>m/s(3.5μm/s). We knew that we could remove one cell layer by using laser at the 1W/cm^2 powers. The cutting velocity of target tissues is estimated as approximately 1μm/s, if the diameter of laser beam becomes 2mm and we have 10mm at the thickness of target tissues.

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