書誌事項
- タイトル別名
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- Study on Mixed-mode Solid-phase Extraction for Drug Screening in Human Serum
- 技術報告 血清中医薬品のスクリーニングを目的としたミックスモード型固相抽出法の検討
- ギジュツ ホウコク ケッセイ チュウ イヤクヒン ノ スクリーニング オ モクテキ ト シタ ミックスモードガタ コソウ チュウシュツホウ ノ ケントウ
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説明
Mixed-mode solid-phase extraction methods were compared for drug screening, prior to gas chromatography/mass spectrometry (GC/MS) and/or liquid chromatography/mass spectrometry (LC/MS). The extractions with Oasis® MCX, ISOLUTE® HCX and Bond Elut Certify® were evaluated by recoveries of acetaminophen, bromvalerylurea, phenobarbital, pentobarbital, amobarbital, chlorpromazine, levomepromazine, promethazine, flunitrazepam, and nitrazepam from human serum. The recoveries were low (0% to 42%) with Bond Elut Certify® for drugs examined except for bromvalerylurea (117%). The recoveries with ISOLUTE® HCX were high (80% to 110%) for all drugs except acetaminophen (33%). The recoveries with Oasis® MCX ranged from 54% to 116% for all drugs including acetaminophen (111%) by using acetonitrile as eluting solvents. The detection limit of each compound ranged 5 to 50 ng on column under scan modes of GC/MS or LC/MS and 0.05 to 0.5 ng on column under SIM modes.<br> This study suggests that Oasis® MCX is a suitable disposable cartridge in routine drug screening in forensic toxicological analysis.<br>
収録刊行物
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- 日本鑑識科学技術学会誌
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日本鑑識科学技術学会誌 9 (1), 71-78, 2004
日本法科学技術学会
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詳細情報 詳細情報について
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- CRID
- 1390001204482999040
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- NII論文ID
- 130004853097
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- NII書誌ID
- AA11919867
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- ISSN
- 18822827
- 13428713
- http://id.crossref.org/issn/03870022
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- NDL書誌ID
- 6882611
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDLサーチ
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
