Bone Mineral Density in Children with GH Deficiency

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  • Nimura Atsuko
    Department of Endocrinology & Metabolism, National Children's Medical Research Center
  • Ikema Shoko
    Division of Endocrinology & Metabolism, National Children's Hospital
  • Goto Masahiro
    Division of Endocrinology & Metabolism, National Children's Hospital
  • Ishikawa Mika
    Division of Endocrinology & Metabolism, National Children's Hospital
  • Kitanaka Sachiko
    Department of Endocrinology & Metabolism, National Children's Medical Research Center
  • Katsumata Noriyuki
    Department of Endocrinology & Metabolism, National Children's Medical Research Center
  • Tanae Ayako
    Division of Endocrinology & Metabolism, National Children's Hospital
  • Hibi Itsuro
    Division of Endocrinology & Metabolism, National Children's Hospital
  • Tanaka Toshiaki
    Department of Endocrinology & Metabolism, National Children's Medical Research Center

Description

The bone mineral density (BMD) of the 2nd metacarpal bone of the left hand was measured in 14 children with complete GH deficiency (CGHD) and 21 children with partial GH deficiency (PGHD) by the digital image processing (DIP) method. In the pretreatment patients, mean BMD in CGHD was significantly lower than that in normal children. The BMD standard deviation (SD) score in the patients with CGHD who had started the GH treatment before 10 years of age increased by approximately 1.5 SD during GH treatment, while that in the patients with PGHD did not change significantly. Since BMD did not show a pubertal increase in the patients who received combined GH and LHRH analog treatment, their BMD SD score decreased by approximately 1.5 SD. The data demonstrate that GH influences BMD, and the level of BMD in patients with GHD should be followed in a longitudinal observation.

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