A study of prophylactic antibiotic one-day medication in the critical path for the distal gastrectomy

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  • 幽門側胃切除術のクリティカルパスにおける予防的抗菌薬1日投与法の検討
  • ユウモンガワ イ セツジョジュツ ノ クリティカルパス ニ オケル ヨボウテキ コウキンヤク 1ニチ トウヨホウ ノ ケントウ

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The critical path for the distal gastrectomy, which was shortened prophylactic antibiotic medication from three days after surgery to the operation day alone, is being tried in our hospital. It was compared about the validity of this critical path concerning about postoperative complications (especially, infection). [Patients and method] The A group for 3 days antibiotic medication after surgery was consisted of 109 patients until October from January in 2001, and the B group for one day medication was consisted of 137 patients from October in 2001 to October in 2002. As for the antibiotic, FMOX of 1g was intravenously infused before and after surgery (A group, B group), on the other hand, it was infused two times per day on the operating day and 3 days after surgery (A group). [Result] 1. Though there were more men in the B group than in the A group significantly, there was no difference in the age, stage, surgical procedures, duration of the hospital stay after surgery. The frequency of the past history was higher in the B group significantly. 2. There was no difference about postoperative complications, 21.1% of the A groups and 19.0% of the B groups, respectively. As for infection, there was also no difference between two groups. 3. There was no difference in a change of fever for three days after surgery. The frequency of the febrile cases (more than 37.5 degrees after the 4th postoperative day) was 24.8% in the A group and 31.4% in the B group, and there was no difference for the antibiotic re-medication rate, 10.1% in the A group and 19.7% in the B group, respectively. 4. The B group showed higher leukocyte count and CRP than the A group on the 7th postoperative day due to more often occurrence of postoperative pancreatitis. [Conclusion] Critical path of distal gastrectomy with prophylactic antibiotic one-day medication method was appropriate, and continuous use would be possible.

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