ニトロソアミンの生体内運命と代謝活性化

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The biological fate of nitrosamines, known as environmental carcinogens, and their metabolic activation in biological system are reviewed. This article includes the absorption, distribution, metabolism and excretion of dimethylnitrosamine, alkylation of nucleic acid bases with nitrosamines, metabolic activation of dialkylnitrosamines to produce alkyl cations as alkylating agents via α-hydroxylation, and the effects of substituents of α-carbon of dialkylnitrosamines on their biological activities. Emphasis has been placed to α-acetoxyalkylnitrosamines as masked compounds of α-hydroxylated active species. Their chemistry, carcinogenicity, and mutagenicity are compared. Organospecific carcinogenicity of dibutylnitrosamine and N-butyl-N-(4-hydroxybutyl) nitrosamine, urinary bladder carcinogens, are explained in terms of metabolism and metabolic activation.

収録刊行物

  • 衛生化学

    衛生化学 24 (6), 271-290, 1978

    公益社団法人 日本薬学会

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