Hepatotoxicity and Immunotoxicity of 1-Bromohexane and Its Glutathione Conjugation in Female BALB/c Mice
-
- Lee Sang Kyu
- College of Pharmacy, Yeungnam University
-
- Lee Dong Ju
- College of Pharmacy, Yeungnam University
-
- Ha Hyun Woo
- College of Pharmacy, Yeungnam University
-
- Yoo Jin Woo
- College of Pharmacy, Yeungnam University
-
- Ko Gyu Sub
- College of Pharmacy, Yeungnam University
-
- Kang Mi Jeong
- College of Pharmacy, Yeungnam University
-
- Kang Wonku
- College of Pharmacy, Catholic University of Daegu
-
- Jeong Hye Gwang
- College of Pharmacy, Chungnam National University
-
- Lee Kyung Bok
- College of Medicine, Konyang University
-
- Jeong Tae Cheon
- College of Pharmacy, Yeungnam University
この論文をさがす
抄録
Hepatotoxic and immunotoxic effects of 1-bromohexane (1-BH) and its conjugation with glutathione (GSH) were investigated in female BALB/c mice. The animals were treated once orally with 1-BH at 500, 1000, and 2000 mg/kg in corn oil for a dose-response study or treated orally with 1-BH at 2000 mg/kg for 6, 12, 24, and 48 hr for a time-course study. Treatment with 1-BH increased serum activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) dose dependently. The hepatic contents of thiobarbituric acid reactive substances were significantly increased at 2000 mg/kg of 1-BH from 12 to 24 hr after the treatment. Oral 1-BH at 2000 mg/kg significantly suppressed production of splenic intracellular interleukin (IL)-2 in response to concanavalin A. Following treatment with 1-BH, three GSH conjugates such as S-hexyl GSH, S-hexyl cysteine, and hydroxyhexyl mercapturic acid were identified in livers by liquid chromatography-electrospray ionization tandem mass spectrometry. The hepatic contents of GSH were maximally decreased 6 hr after treatment with 1-BH. GSH conjugates were also detected maximally in livers 6 hr after treatment. These results suggest that 1-BH could cause hepatotoxicity and immunotoxicity as well as depletion of GSH content due to the formation of GSH conjugates with 1-BH in female BALB/c mice.
収録刊行物
-
- JOURNAL OF HEALTH SCIENCE
-
JOURNAL OF HEALTH SCIENCE 56 (4), 434-441, 2010
公益社団法人 日本薬学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390001204497121024
-
- NII論文ID
- 130000303542
-
- NII書誌ID
- AA11316464
-
- ISSN
- 13475207
- 13449702
-
- NDL書誌ID
- 10764113
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可