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- Cannavò Andrea
- Institute of Forensic Medicine (Occupational Medicine Section), University “La Sapienza”
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- Ceci Paola
- Institute of Forensic Medicine (Occupational Medicine Section), University “La Sapienza”
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- Coletti Dario
- Department of Histology and Medical Embryology, University “La Sapienza”
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- Cortesi Maurizio
- Operative Unit of Clinical Pathology, Hospital San Giovanni Calibita-Fatebenefratelli
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- Papa Fabrizio
- Operative Unit of Clinical Pathology, Hospital San Giovanni Calibita-Fatebenefratelli
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- Vivarelli Elisabetta
- Department of Histology and Medical Embryology, University “La Sapienza”
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- Tomei Francesco
- Institute of Forensic Medicine (Occupational Medicine Section), University “La Sapienza”
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- Adamo Sergio
- Department of Histology and Medical Embryology, University “La Sapienza”
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- Naro Fabio
- Department of Histology and Medical Embryology, University “La Sapienza”
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説明
Polychlorinated biphenyls (PCBs) are molecules structurally related to dioxins and were widely used in the past in industrial applications. Their chemical stability and high lipophilicity make them persistent pollutants and dangerous occupational contaminants. Our previous results showed that “low concentrations” of PCBs (≤ 10 μg/ml, using the commercial mixture Aroclor 1254) inhibit in vitro hormonal induced myogenic differentiation. Here we extend the notion of PCBs as inhibitors of myogenic differentiation induced by lower serum medium. Aroclor 1254 treatment of myogenic cells, induced to differentiate in low serum medium, inhibits (at concentrations ≤ 10 μg/ml) the extent of fusion and the size of the myotubes as well as the accumulation of sarcomeric myosin. We also investigated whether the cell mortality observed at Aroclor 1254 concentrations ≥ 10 μg/ml is due to necrosis or to apoptosis. Using different approaches, we observed that Aroclor 1254 causes necrosis but not apoptosis of myogenic cells in a dose-dependent manner. In addition, we report that Aroclor 1254 induces release of the intracellular enzymes lactate dehydrogenase (LDH) and creatine kinase (CK) in a dose-dependent manner. These results may explain the CK serum elevation observed in patients exposed to high doses of PCBs.<br>
収録刊行物
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- JOURNAL OF HEALTH SCIENCE
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JOURNAL OF HEALTH SCIENCE 50 (1), 33-41, 2004
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204497430016
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- NII論文ID
- 110003609125
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- NII書誌ID
- AA11316464
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- ISSN
- 13475207
- 13449702
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- NDL書誌ID
- 6828329
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可