Identification of Dimethylmatairesinol as an Immunoglobulin E-suppressing Component of the Leaves of Cinnamomum camphora
-
- Tanabe Hiroki
- Graduate School of Nutritional and Environmental Sciences, University of Shizuoka
-
- Fukutomi Ryuuta
- Nisshin Seifun Group Inc.
-
- Yasui Kensuke
- Health Care Research Center, Nisshin Pharma Inc.
-
- Kaneko Akihiro
- Health Care Research Center, Nisshin Pharma Inc.
-
- Imai Shinjiro
- Nisshin Seifun Group Inc.
-
- Nakayama Tsutomu
- Graduate School of Nutritional and Environmental Sciences, University of Shizuoka
-
- Isemura Mamoru
- Graduate School of Nutritional and Environmental Sciences, University of Shizuoka
Search this article
Abstract
Immunoglobulin E (IgE) plays an important role in allergic diseases. In this study, we found that a methanol extract of leaves of the camphor tree Cinnamomum camphora (C. camphora) reduced the amount of IgE secreted by human myeloma U266 cells. When the methanol extract was fractionated by extraction with organic solvents, the ethyl acetate fraction showed the highest activity. The fraction was further separated into several subfractions by preparative TLC. We identified the component of one of the active subfractions as dimethylmatairesinol. Authentic dimethylmatairesinol exhibited similar activity. Thus, the extract of C. camphora and its components including dimethylmatairesinol have potential as an anti-allergic agent.
Journal
-
- Journal of Health Science
-
Journal of Health Science 57 (2), 184-187, 2011
The Pharmaceutical Society of Japan
- Tweet
Details 詳細情報について
-
- CRID
- 1390001204497480192
-
- NII Article ID
- 130000663118
-
- NII Book ID
- AA11316464
-
- ISSN
- 13475207
- 13449702
-
- NDL BIB ID
- 11024845
-
- Text Lang
- en
-
- Data Source
-
- JaLC
- NDL
- Crossref
- CiNii Articles
-
- Abstract License Flag
- Disallowed