Oral Acute and Subacute Toxicity Studies with Kalpaamruthaa, a Modified Indigenous Preparation, on Rats

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  • Mythilypriya Rajendran
    Department of Medical Biochemistry, Dr. ALM. Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus
  • Shanthi Palanivelu
    Department of Pathology, Dr. ALM. Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus
  • Sachdanandam Panchanatham
    Department of Medical Biochemistry, Dr. ALM. Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus

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Kalpaamruthaa (KA), a modified indigenous Siddha formulation constitutes Semecarpus anacardium nut milk extract, Emblica officinalis and honey. KA is evaluated for its behavioral and toxicological effects and also its consequence on biochemical and histological variations. Acute and subacute toxicity studies with KA were done on Wistar Albino rats. During acute toxicity study (72 hr), there were no any adverse effects found in the general behavior and mortality at any dose level given (50-2000 mg/kg b.wt.). In subacute toxicity study (30 days) KA (50, 100, 250 and 500 mg/kg b.wt.) did not cause any changes in hematological and biochemical parameters with the exception of a transient rise in hemoglobin, leukocyte count, free fatty acid, plasma and urine creatinine and a significant decrease in blood glucose, total cholesterol, triglyceride and phospholipid levels. The changes observed are significant only at the highest dosage of 500 mg/kg b.wt. Further, histopathological examination of vital organs showed normal architecture suggesting no morphological disturbances; it can be considered that KA is safe and non toxic.

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