Oral Acute and Subacute Toxicity Studies with Kalpaamruthaa, a Modified Indigenous Preparation, on Rats
-
- Mythilypriya Rajendran
- Department of Medical Biochemistry, Dr. ALM. Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus
-
- Shanthi Palanivelu
- Department of Pathology, Dr. ALM. Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus
-
- Sachdanandam Panchanatham
- Department of Medical Biochemistry, Dr. ALM. Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus
この論文をさがす
説明
Kalpaamruthaa (KA), a modified indigenous Siddha formulation constitutes Semecarpus anacardium nut milk extract, Emblica officinalis and honey. KA is evaluated for its behavioral and toxicological effects and also its consequence on biochemical and histological variations. Acute and subacute toxicity studies with KA were done on Wistar Albino rats. During acute toxicity study (72 hr), there were no any adverse effects found in the general behavior and mortality at any dose level given (50-2000 mg/kg b.wt.). In subacute toxicity study (30 days) KA (50, 100, 250 and 500 mg/kg b.wt.) did not cause any changes in hematological and biochemical parameters with the exception of a transient rise in hemoglobin, leukocyte count, free fatty acid, plasma and urine creatinine and a significant decrease in blood glucose, total cholesterol, triglyceride and phospholipid levels. The changes observed are significant only at the highest dosage of 500 mg/kg b.wt. Further, histopathological examination of vital organs showed normal architecture suggesting no morphological disturbances; it can be considered that KA is safe and non toxic.
収録刊行物
-
- JOURNAL OF HEALTH SCIENCE
-
JOURNAL OF HEALTH SCIENCE 53 (4), 351-358, 2007
公益社団法人 日本薬学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390001204497521664
-
- NII論文ID
- 110006366911
-
- NII書誌ID
- AA11316464
-
- ISSN
- 13475207
- 13449702
-
- NDL書誌ID
- 8829280
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDLサーチ
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可