Effect of Marine Algae Extract on Bone Calcification in the Femoral-metaphyseal Tissues of Rats: Anabolic Effect of Sargassum horneri.
-
- Yamaguchi Masayoshi
- Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka
-
- Hachiya Sachiko
- Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka
-
- Hiratuka Seiichi
- Functional Food Project Team, Shizuoka Industrial Research Institute of Shizuoka Prefecture
-
- Suzuki Toshihiro
- Functional Food Project Team, Shizuoka Industrial Research Institute of Shizuoka Prefecture
この論文をさがす
抄録
The effect of various algae on bone calcification in the femoral-metaphyseal tissues of rats was investigated. Undaria pinnatifida, Sargassum horneri, Eisenia bicyclis, Cryptonemia scmiziana, Gelidium amansii, and Ulva pertusa Kjellman, which were gathered seasonally, were used. Water suspensions (5%) of marine algae powder were orally administered once daily for 7 days. Bone calcium content was significantly increased by the administration of U. pinnatifida, S. horneri, E. bicyclis, or C. scmitziana. Bone alkaline phosphatase activity, which is an enzyme for calcification, was significantly enhanced by the administration of S. horneri or G. amansii. Femoral-metaphyseal tissues were cultured for 48 hr in Dulbecco’s modified Eagle’s medium containing either vehicle or water-solubilized extract (25 and 50 μg/ml) obtained from U. pinnatifida, S. horneri, E. bicyclis, and C. scmitziana. The bone calcium content was significantly elevated in the presence of S. horneri extract (25 and 50 μg/ml). No effect was seen with other extracts. The effect of S. horneri extract in increasing bone calcium content was completely inhibited in the presence of cycloheximide (10-6 M), an inhibitor of protein synthesis. The present study demonstrates that S. horneri extract has an anabolic effect on bone calcification in vivo and in vitro. The anabolic effect of S. horneri extract may be based on a newly synthesized protein component.
収録刊行物
-
- JOURNAL OF HEALTH SCIENCE
-
JOURNAL OF HEALTH SCIENCE 47 (6), 533-538, 2001
公益社団法人 日本薬学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390001204498120704
-
- NII論文ID
- 110003641444
-
- NII書誌ID
- AA11316464
-
- COI
- 1:CAS:528:DC%2BD3MXptVOisLk%3D
-
- ISSN
- 13475207
- 13449702
-
- NDL書誌ID
- 5995748
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可