Suppression of the Melanogenesis and Cellular Antioxidant Activity in B16 Melanoma Cells

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  • B16メラノーマ細胞におけるメラニン産生抑制と抗酸化活性 (Cellular Antioxidant Activity)
  • B16 メラノーマ サイボウ ニ オケル メラニン サンセイ ヨクセイ ト コウサンカ カッセイ Cellular Antioxidant Activity

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Abstract

The results of antioxidant activities by ORAC assay and CAA assay were evaluated for melanogenesis. Although the antioxidant activity by ORAC was not correlated with the melanogenesis, the samples which showed high antioxidant activity by CAA tended to suppress melanogenesis. Caffeic acid and Citrus depressa juice, which demonstrated inhibitory effects on melanogenesis, had high antioxidant activities but no inhibitory effects on tyrosinase activity. In addition, they inhibited the melanogenesis which was increased by inhibition of catalase activity. These results may suggest that antioxidant activity by CAA can contribute to the suppression of melanogenesis in B16 melanoma.

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