Comparative Results of Air Flow Characters Mapped by CFD Simulation and Actual Measurements of Three Dimensional Air Flow Vectors and Particle Concentrations

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  • Katayama Hirohito
    Astellas Pharma Inc. Pharmaceutical Research and Technology Laboratories
  • Katoh Shigeo
    Kobe University Graduate School of Engineering Faculty of Engineering

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  • 医薬品製造無菌室の気流の数値流体力学（ＣＦＤ）を使ったコンピュータシミュレーションと実測空中微粒子濃度，実測３次元気流の結果比較と考察
  • イヤクヒン セイゾウ ムキンシツ ノ キリュウ ノ スウチ リュウタイ リキガク CFD オ ツカッタ コンピュータ シミュレーション ト ジッソク クウチュウ ビリュウシ ノウド ジッソク 3ジゲン キリュウ ノ ケッカ ヒカク ト コウサツ

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Distribution maps of local age of air and air flow velocity produced by CFD simulation were compared with actual measurements of particle concentrations at eighteen monitoring points as well as three-dimensional air flow vectors 1-m grids in an aseptic pharmaceutical manufacturing room. As a result the air flow patterns assessed by both approaches of simulation with the standard κ–ε model and actual air vector measurements were comparable under conditions of high air change times aseptic room. In this case study particle concentration and local age of air showed no clear relationship due to very low counts of particles. However, CFD simulation displayed its advantages in giving comprehensive air flow pattern and recovery efficiency at local points in an aseptic room.

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