Dissolution Characteristics of Compressed Tablets

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  • Ito Ryusei
    Division of Materials Science and Engineering, Graduate School of Engineering, Hokkaido University
  • Nishimura Manabu
    Division of Materials Science and Engineering, Graduate School of Engineering, Hokkaido University
  • Golman Boris
    Division of Materials Science and Engineering, Graduate School of Engineering, Hokkaido University
  • Shinohara Kunio
    Division of Materials Science and Engineering, Graduate School of Engineering, Hokkaido University
  • Fukunaka Tadashi
    Division of Materials Science and Engineering, Graduate School of Engineering, Hokkaido University

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Other Title
  • 錠剤状圧密充填体の溶解特性
  • ジョウザイジョウアツミツジュウテンタイ ノ ヨウカイ トクセイ

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Abstract

The dissolution rate of medical tablets has hitherto been measured by repeating dissolution tests, which require considerable time to get experimental confirmation of dissolution characteristics. Thus, it has not been investigated from the viewpoint of prescription of the dissolution rate. In this paper, the effects of tablet compaction and primary-particle properties on the dissolution rate were studied experimentally and quantitatively. It was found that the dissolution rate increased with increasing voidage of the tablet, increasing shape index of primary particles, decreasing active component and with decreasing specific surface diameter. The effect of shape index should, therefore, be considered by constructing a new dissolution model, because it is of an equal level to the effect of the specific surface diameter.

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