Anhydrate Transformation of Hydrate Crystals of a Thiazol Acid in Metanol Aqueous Solution.

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  • Koga Keiichi
    Technological Development Laboratory, Fujisawa Pharmaceutical Co., Ltd.
  • Hirabayashi Satoshi
    Technological Development Laboratory, Fujisawa Pharmaceutical Co., Ltd.
  • Kagara Kooji
    Technological Development Laboratory, Fujisawa Pharmaceutical Co., Ltd.

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  • メタノール水溶液におけるチアゾール酸水和物の無水転移
  • メタノール スイヨウエキ ニ オケル チアゾールサン スイワブツ ノ ムスイ

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Abstract

For the development of a new crystallization method to steadily transform hydrate crystals of a thiazol acid, (Z) - [4- (2-aminothiazolyl)] -2-methoxyiminoethanoic acid, to the anhydrate form, it was confirmed that aqueous methanol solutions were the most suitable solvents for the transformation and various crystallization experiments were carried out using the solvents.<BR>Influences of composition of solvent, crystallization temperature, seed crystals and agitation speed on transformation rate were studied.<BR>On the basis of these results, a crystallization method to obtain the desired anhydrate crystals was established.

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