書誌事項
- タイトル別名
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- Preparation and Tableting of Granules Produced by the Extrusion Method.
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説明
The objective of the present study is to verify that tablets, which are superior in physical properties, dissolution characteristics, and drug content uniformity, can be manufactured directly from granules prepared by an extrusion granulation process. First, granules were experimentally produced by extrusion, by changing the hole diameter and thickness of screen of granulator, the binder content, and the binder adding method. A fraction of the extruded granules were crushed and then sized. Tablets were manufactured from both extruded and crashed granules. As a result, it is possible to manufacture tablets which meet the targeted properties: tablet hardness ≥40N; disintegration time≥300s directly from the extruded granules without crushing and sizing. The tablets showed superior dissolution characteristic despite their high hardness. In addition, the drug content is uniform over the tablets even when the model drug content is extremely small (1wt%). The targeted physical properties can be obtained by adding 0.5wt% powder binder when the screen hole diameter (0.5mm) is smaller than the screen thickness (0.6mm), or by adding 1.5wt% powder binder when the screen hole diameter (0.5mm) is larger than the screen thickness (0.4mm).
収録刊行物
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- 粉体工学会誌
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粉体工学会誌 37 (12), 852-861, 2000
一般社団法人 粉体工学会
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詳細情報 詳細情報について
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- CRID
- 1390001204513357440
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- NII論文ID
- 130003777697
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- ISSN
- 18837239
- 03866157
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
- OpenAIRE
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- 抄録ライセンスフラグ
- 使用不可