書誌事項
- タイトル別名
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- Application of Electrospray Deposition for Preparing Nanoparticulate Formulation of Poorly Soluble Drugs
- エレクトロスプレーホウ オ リヨウ シタ ナン スイヨウセイ ヤクブツ ノ ナノ リュウシ セイザイカ
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Many formulation technologies have been developed to overcome low-solubility problem of drug candidates. Herein introduced is the application of the electrospray technology as a new option. This method can produce solid amorphous nanoparticles in one-step. Moreover, it can be operated under ambient condition. In the first part of this paper, effect of solution and operation parameters on the particle formation was extensively investigated using chitosan / acetic acid aqueous solutions. Solution viscosity and conductivity were the most important parameters to affect particle size and even the availability of the formulation. The scaled-up study was performed using 8-nozzle manifold, by which prednisolone formulation was prepared with poly (vinyl pyrrolidone) K90. Although the solution of low concentration was preferred to obtain small particles, that of high concentration was favored for effective amorphization. The coaxial nozzle was used to control the surface characteristic of the particle. Dissolution rate of griseofulvin was significantly enhanced by coating the surface by Eudragit L-100.
収録刊行物
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- 粉体工学会誌
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粉体工学会誌 48 (3), 167-172, 2011
一般社団法人 粉体工学会
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詳細情報 詳細情報について
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- CRID
- 1390001204513400448
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- NII論文ID
- 10027915959
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- NII書誌ID
- AN00222757
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- ISSN
- 18837239
- 03866157
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- NDL書誌ID
- 11042194
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可